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Corrositex Continuous Time Monitor Assay

The Corrositex® assay is a standardized and quantitative in vitro test developed as a replacement for the dermal corrosivity rabbit test. The Corrositex kit, manufactured by In Vitro International (IVI), uses a proprietary biobarrier membrane to model the skin for evaluating the potential dermal corrosivity of a test material.

A test material is evaluated based on its penetration through the biobarrier membrane into a Chemical Detection System (CDS). The time required for the test material to break through the biobarrier and into the CDS is determined. A U.S. Department of Transportation (USDOT) packing group is assigned based on the break through time.

The Corrositex® assay is presently the only in vitro assay approved by the U.S. Department of Transportation for testing potential corrosive materials and assigning packing group categories.

Assay Design: Quick Facts

Assay Model: proprietary biobarrier membrane

Detection Agent: CDS (chemical detection system)

Endpoint: the time required for a corrosive material to break through the membrane

For more information about testing your materials using this assay, please see Applications. Specialized protocols may be prepared as requested through consultation with an IIVS Study Director.

Corrisitex® Assay